Comparison Of NAG-1 (Nonsteroidal Anti-inflammatory Drug-Activated Gene-1) Expression In Human Gastric Carcinoma And Normal Gastric Mucosa

Background & AimsGastric cancer is the mostly common disease in china .Its mortality rate ranks first in various tumors. Epidemiologic studies have shown that people who regularily take aspirin or other nonsteroidal anti-inflammatory drugs are at reduced risk of developing from gastric carcinoma by about 50%. The antitumorigenic activity of NSAIDs is mediated through the inhibition of cyclooxygenase-2(COX-2)which has been illustrated by many animal experiments, cell research in vitro and some clinical trials. However, the NSAIDs may suppress tumorigenesis partially independent of COX inhibition. The nonsteroidal anti-inflammatory drug activated gene 1(NAG-1) is a transforming growth factor β superfamily member that has proapoptotic and antitumorigenic activities whose expression increases after exposure to NSAIDs.NAG-1 is one of the several important mediators acting independent of COX inhibition. By now, we have not known whether the NAG-1 and NAG-1 mRNA are expressed in gastric carcinoma and normal gastric mucosa or not.Is there difference of NAG-1 expression between them? The aim of study was to detect the expression of NAG-1 and NAG-1 mRNA in gastric carcinoma, adjacent normal tissue and normal gastric mucosa, to investigate the possible role of NAG-1 in the carcinogenesis and development of gastric carcinoma, to supply experiment evidence for the clinical application of...