A Clinic Correlation Of Serum Leptin With Liver Function In Chronic Sever Hepatitis: A Case Clinic Study

Objective: to investigate the significance and correlations with the severity of liver disease ,and serum leptin levels in chronic sever hepatitis ,chronic hepatitis and hepatic cirrhosis. Methods: 55 cases with chronic sever hepatitis patients, 42 cases with chronic hepatitis ,22 cases with hepatic cirrhosis and 55 healthy persons as controls were enrolled in this study. Serum leptin levels were determined by radioimmunoassay (RIA). The biochemical liver function ALT,AST,TBIL, ALB ,PT and CHO were detected at the same time. The correlations of serum leptin levels with PT,CHO and biochemical liver function were assessed statistically. A linear regression analysis was performed with serum leptin levels as dependent variable and age, TBIL, TBA, AST, ALB, ALT, CHO as independent variables in chronic sever hepatitis ,chronic hepatitis and hepatic cirrhosis. Between whole and sub-group comparisons were performed by non-parametric K Independent Samples tests.. A p value of <0.05 was considered statistically significant. Results: A linear regression analysis was performed with serum leptin levels as dependent variable and age, TBIL, TBA, AST, ALB, ALT, CHO as independent variables .In 55 cases with chronic sever hepatitis, age,TBIL, ALT and CHO were influencing factor of serum leptin. Between whole and sub-group comparisons were performed by non-parametric K Independent Samples tests. Serum leptin levels were significantly higher in chronic sever hepatitis group (10. 2296±2. 9136) and chronic hepatitis group (9. 3310±1. 1929) than controls (P=0. 000,...