Biocompatibility Evaluation Of The Four Kinds Of Bone-rehabilitate Biomaterial In Vitro

Objective: To evaluate the biocompatibility of hydroxyapatite , high-density and high-intensity polyethylene , polycaprolactone and silicon in vitro. Methods: Four kinds of biomaterials were implanted into muscles of rats. After 2,4,8 and 12 weeks, the gross, histopathological and transmission electron microscope examination were observed to evaluate the biocompatibility of above biomaterials. Results: The films of the high-density and high-intensity polyethylene and polycaprolactone had mild inflammatory reaction in the early days of planting and after 12 weeks the inflammation basically disappeared. The inflammation reaction of HA and silicon outweight the above two materials. The high-density and high-intensity polyethylene have close relationship with around tissues and possess good biocompatibility. Polycaprolactone is a kind of material with good biocompatibility and biodegradation. Conclusion: The present study suggests that the high-density and high-intensity polyethylene and polycaprolactone have good biocompatibility, no toxin and antigen free. Therefore , these two biomaterials should be used in the reconstruction of bone deformities.