Clinical Study Of Different Dosage Simvastatin On The Uighur Acute Coronary Syndrome Patients In Achieving Target Blood Lipid Level After Short Time Medication

Objective: This study is designed to evaluate the efficacy and safety of different dosage simvastatin on the acute coronary syndrome (ACS) patients with lipid disorders after short time medication. Method: according to the International Heart Association and WHO criteria of diagnosis, choose some uighur patients who diagnosed as ACS, measure their blood lipid level and liver function (TC, TG, LDL-C, HDL-C, ALT, AST, CK). According to the China Heart Association Suggestions, 100 ACS patients with lipid disorders were devided into two groups randomly, group A (n=50), was given simvastatin 40mg/d at night; group B (n=50) was given simvastatin 20mg/d at night. blood lipid level and liver function were measured after one week treatment. Result: there were significant reduction of TC, LDL-C and higher target blood-lipid goal rate in group A compared with group B. group A is effective in reducing TG. In both group adverse reaction is mild, similar. Conclusion: ACS patients with lipid disorders in ethnic Uighur population, the early usage of simvastatin 40mg/d seems very effective in hightenirg target blood-lipid goal rate after short time medication. Simvastatin 40mg/d will be good in safety, efficacy and tolerance.