Effects Of Simvastatin In Deferent Dosage On Plasma Levels Of Hs-CRP,Hcy And VWF In Patients With Acute Coronary Syndrome

Background Acute coronary Syndrome is an important occurrence in the procedure of atheromatosis, which conversion has a direct impact on the patient with coronary heart disease. Investigation thinks the stability of plaque has a decisive action in the acute coronary syndrome. And studies had made clear that statins could improve the endothelium function and stabilize the quality of plaque .So statins can improve the prognosis of the patients with acute coronary syndrome. But if statins could produce a marked effect in short-term is not clear. Something should be done to make sure whether statins can improve condition in short period in patients with acute coronary syndrome.Objective To observe whether intervention with two different dosage of simvastatin and common dosage of atorvastatin may benefit to plasma levels of high-sensitive C reactive protein (Hs-CRP), homocysteine (Hey) and von Willebrand factor (vWF) in patients with acute coronary syndrome.Methods Patients of acute coronary syndrome were randomly assigned into four groups: the control group (n=15) treated without lipid-lowering drugs, 20mg (n=15) and 40mg ( n=18) simvastatin group with 3 days of treatment. Before and after the treatment, the plasma levels of Hs-CRP, Hey, vWF and lipid were detected.Result Treatments of 20mg simvastatin did not induced the significant decrease of Hs-CRP, Hey and vWF. Compared to the control group, levels of Hs-CRP, Hey and vWF were markedly reduced by 40mg simvastatin (Hs-CRP 47.0% vs 4.3%, Hey 36.6% vs 0.9%, vWF 19.0% vs 4.8%, P<0.05).No changes of lipid levels were observed in any group before and after treatment, whilst with 40mg/d simvastatin there were no relation between the decrease percent of Hs-CRP, Hey or vWF and that of TC or LDL(r=0.229, P=0.361; r=0.142, P=0.574; r=0.131, P=0.605), LDL-C (r= -0.020, P=0.936; r= -0.112, P=0.659; r= -0.321, P=0.194).Conclusion Treatments with high-dose simvastatin (40mg/d) for 3 days could reduce the levels of inflammatory factors and Hey and improved the function of vascular endothelium, thus it promotes the stabilization of atherosclerotic plaque.