A Preliminary Study On Quantified Standards Of TCM Syndromes Of Female Sterility

BackgroundSterility is a question widespread throughout the world, and has a tendency to increase year after year. With modern lifes work stress, the environments food pollution, the use of various chemical compounds, repeated reproductive tract infections and etc, sterility patients will increase every year. TCM for the treatment of sterility effect has been widely acknowledged. Since subjectivity of TCM differential diagnosis, disease diagnosis and efficacy evaluation standards lack of normative and objectivity, which constrains sterility further research and promotion of TCM treatment. However syndromes theory has provided feasibility guarantee for standardized and objective of TCM differential diagnosis. ObjectivesThe study seeks to explore distribution patterns of TCM syndromes of female sterility, to lay the foundation to work out the objective, applicabile and workable standards of syndromes for clinical. MethodsUsing the method of combining literature research, expert advices clinical epidemiological investigation with mathematical statistics, to draw up information collection table from four methods of physical examination of TCM syndromes for sterility;and to set up database. Useing descriptive analysis, cluster analysiss computing weights normality plots with tests percentiles and etc, to make a preliminary study on quantified standards of TCM syndromes of sterility, and to set up workable diagnostic standards of syndromes for clinical initially. Results1. After collating and classifying, 154 articles in the literaturestandards have been involved into 11 syndrome patternso Kidney-asthenia pattern (238 cases) is the most syndrome pattern, next are blood stasis pattern(129 cases) > phlegm-wetness pattern (93 cases) ? stagnation of liver-energy pattern (92 cases) .. deficiency of vital energy and blood pattern (64 cases) ? wetness-heat pattern (51 cases) > cold-evil pattern (29 cases) and stagnation of liver-energy and kidney-asthenia pattern (10 cases) which are relatively more. Blood-heat pattern (5 cases) ., phlegm-heat pattern (1 case) and deficiency of spleen-yang pattern (1 case) is rare.2. In clinical sterility patients according with standard is a total of 422 cases, through differential diagnosis, the experts divide them into 16 patterns. Sterility gives the priority to compound pattern. Kidney-asthenia and blood stasis pattern (77 cases) is the most syndrome pattern. Next is kidney-asthenia pattern (65 cases) ? blood stasis and wetness-heat pattern(53 cases)>kidney~asthenia and stagnation of liver-energy pattern(50 cases)> stagnation of liver-energy and blood stasis pattern(46 cases)>kidney-asthenia and phlegm-wetness pattern (45 cases) -. kidney-asthenia and wetness-heat pattern (27 cases) % blood stasis and phlegm-wetness pattern (11 cases) -. wetness-heat patternGl cases)which are relatively more. Blood stasis pattern(8 cases) n stagnation of liver-energy and wetness-heat pattern (8 cases) ^ stagnation of liver-energy pattern (5 cases) ^ deficiency of vital energy and blood pattern (5 cases) > phlegm-wetness pattern (4 cases) > stagnation of liver-energy and phlegm-wetness pattern (3 cases) > kidney-asthenia with deficiency of vital energy and blood pattern (2 cases) are rare. Each complex pattern will be bring into the different single pattern of the corresponding literature research at the same time. So kidney-asthenia pattern is 266 cases(63.03%) in the first. Second, blood stasis pattern is 195 cases (46.21%) . Third, stagnation of liver-energy pattern is 112 cases (26.54%) . Fourth, wetness-heat pattern is 88 cases (20.85%) . Fifth, phlegm-wetness pattern is 63 cases (14.93%) . Sixth, deficiency of vital energy and blood pattern is 7 cases (1.66%) .3.422 cases of clinical cases use cluster analysis for seven categories, and the experts discussed the appropriate name given to. According to the decreasing number of cases are characterized as follows: kidney-asthenia and blood stasis pattern (86 cases) > wetness-heat and blood stasis pattern (85 cases) ? stagnation of liver-energy and blood stasis pattern (65 cases) >kidney-asthenia and stagnation of liver-energy pattern (55 cases) > asthenia of both spleen and kidney (phlegm-wetness) pattern (54 cases) % deficiency of kidney-yang pattern(42 casesK deficiency of kidney-yin pattern(35 cases). Each complex pattern will be bring into the different single pattern of the corresponding literature research at the same time. According to the decreasing number of cases are characterized as follows again: kidney-asthenia pattern 272 cases (64. 45%) > blood stasis pattern 236 cases (55. 92%) ^ stagnation of liver-energy pattern 120 cases (28.44%) .. wetness-heat pattern 85 cases (20.14%) -. spleen-asthenia (phlegm-wetness) pattern 54 cases (12.80%) .4. Quantified standards of TCM syndromes of sterility: Diagnostic threshold of wetness-heat and blood stasis pattern is 25, and classification standards: 25^1ight<31, 31^medium<38, heavy^38. Diagnostic threshold of stagnation of liver-energy and blood stasis pattern is 27, and classification standards: 27 ^ light < 33 , 33 =^ medium < 42 , heavy ^ 42. Diagnostic threshold of kidney-asthenia and stagnation of liver-energy pattern is 24 , and classification standards: 24 ^ light < 30, 30 ^ medium < 40 , heavy ^ 40. Diagnostic threshold of asthenia of both spleen and kidney (phlegm-wetness) pattern is 30, and classification standards: 30^1ight<39, 39^medium<53, heavy^53. Diagnostic threshold of deficiency of kidney-yang pattern is 36, and classification standards: 36^1ight<42, 42^medium<53, heavy^53. Diagnostic threshold of kidney-asthenia and blood stasis pattern is 26, and classification standards: 26 ^ light < 34, 34 ^ medium < 43 , heavy ^43. Diagnostic threshold of deficiency of kidney-yin pattern is 38 , and classification standards: 38^1ight<44, 44^medium<54, heavy^54. Rusults1. In clinical composite pattern of sterility is particularly prevalent. Kidney-asthenia pattern blood stasis pattern^ stagnation of liver-energy patter> wetness-heat pattern, spleen-asthenia (phlegm-wetness) pattern are sterility common pattern. Kidney-asthenia pattern occupies the largest percentage. The distribution pattern reflects the fundamental pathogenesis of sterility.2. Diagnostic threshold and standards for classification of TCM syndromes embodies the effective integration of traditional Chinese medicine theory and modern scientific research methodology. Not only for the clinical selection of treatment based on the differential diagnosis of sterility providedreferent proof, but also the light> medium and heavy degree rating standards of syndromes may provide relative normally initial standards of TCM diagnostic sub-type quantified and efficacy evaluation of this disease for the future.