A Comparison Clinical Study Of Inhibition In-stent Restenosis And Anti-inflammation Effects By Different Dosage Of Atrovastatin

Objective: Basic research indicates that inflammation plays a pivotal role in the in-stent restenosis process by inducing neointimal proliferation after coronary stenting. C-reactive protein and interleukin-8, as important inflammation mediators, have been associated closely with the occurrence of in-stent restenosis. atrovastatin has exerted potent anti-inflammatory and anti-proliferative properties, which maybe potentially interfere with the major process of in-stent restenosis. Therefore, this clinical study was aimed to investigate whether atrovastatin therapy inhibited the in-stent restenosis via anti-inflammation and the relationship between in-stent restenosis and chemokines, such as C-reactive protein and interleukin-8.Methods and materials: The study population consisted of 41 consecutive patients undergoing coronary stent implantation, from December 2004, to May 2005. Patients were randomly divided into group A and B to receive either 20mg or 10mg atrovastatin respectively. Quantitative coronary angiography was performed by fully computerized angiographic analysis. Minimal luminal diameter, reference diameter, lesion length and percent diameter stenosis were measured before...