Effect Of Heme Oxygenase On Calcium Overload And ICAM-1 In Hepatic Ischemia Reperfusion Injury In Rats

Shock, gastrointestinal hemorrhage and liver transplanta- tion operations frequently lead to hepatic metabolism disturbance because of ischemia reperfusion (IR). Hepatic IR injury is a common pathophysiologic process, which usually occurs in many clinical courses. Thus, the purpose of study is to investigate the mechanism of hepatic IR injury and seek the ways of protection against hepatic IR injury.Hepatic IR injury is a complex multiple factor process. At present, the basic mechanism of IR injury may be related to oxygen free radical (OFR) and calcium overload. Inflammation response, the accumulation and adherence of polymorpho- nuclear neutrocyte (PMN), microcirculation disturbance are closely related to the mechanism of IR injury.Heme oxygenase (HO) is the first and rate-limiting enzyme of heme degradation, which breaks down the heme into carbon monoxide (CO), iron, and biliverdin. Recent studies have found that HO and its metabolite may play an important role in mediating protection against inflammatory response, oxidative stress, microcirculation disturbance of hepatic IR injury.Intracellular calcium (Ca²⁺) overload is considered to be...