Effects Of Intravenous Recombinant Human Brain Natriuretic Peptide On Activation Of Neuroendocrine Systems In Acute Myocardial Infarction Patients With Heart Failure

Objective: To compare the effects of intravenous injection of recombinant human brain natriuretic peptide (rhBNP) versus intravenous nitroglycerin (NIT) on neurohormonal activation(including caticholamines, renin, angiotensin II and aldosterone) in the acute myocardial infarction (AMI) patients with heart failure through a prospective study.Methods: Forty-two consecutive patients who suffered from anterior wall AMI with heart failure within 12 to 24 hours from the onset were randomized into rhBNP group(n=21, 1.5μg·kg-1 bolus intravenous injection followed by 0.0075μg·kg-1·min-1 for the first 3 hours and 0.015-0.03μg·kg-1·min-1 infusion for following 21 hours)and NIT group(n=21, 10 to 100μg·min-1 intravenous infusion for 24 hours), Blood samples for measurements of epinephrine, norepinephrine, renin, angiotensin II and aldosterone were taken at four time points: baseline, 6, 24h after administration and 6h postinfusion.Results: 1. There were no significant differences in plasma concentration levels of epinephrine, norepinephrine, renin,...