The Expression And Clinical Significance Of Survivin And Smac In Extrahepatic Cholangiocarcinoma

Objective: Survivin is one of the members of human inhibitor of apoptosis proteins (IAPs) family. Its central mechanism is direct or indirect inhibition of Caspase. Survivin is the most powerful inhibitor of apoptosis as it inhibits Caspase-3 and Caspase-7,the terminal effectors of apoptotic pathway.Smac(Second mitochondrial-derived activator of Caspase, Smac) is the first mammalian RHG protein to be described, and many studies have since demonstrated it can inhibit IAPs by direct binding. In the intrinsic cell death pathway, it is released from the intermembrane space of mitochondria into the cytosol with cyto-c, and binds to a highly conserved surface groove on the BIR domain of IAPs, then inhibiting IAP-mediated apoptosis. The report about Smac investigation in cholangio- carcinoma is not found by now.In this study we detect the expression of Survivin and Smac in extrahepatic cholangiocarcinoma and benign lesion of EHBD (extrahepatic bile duct, EHBD) by immunohisto- chemistry, and investigate the relationship between the expression of Survivin/Smac and differentiation grade, TNM stage and metastasis, in order to discuss their roles and...