Glucocorticoid Reduces The Systemic Inflammatory Response To Cardiopulmonary Bypass

Object: During the process of cardiopulmonary bypass, many factors may result in systemic inflammatory response syndrome (SIRS). Reduce or eliminate the undesirable effects of CPB can improve the body's function of the patients of open heart operation. In recent years, the research that reduce the body's function destroyed with CPB were continuous and use drugs to prevent the inflammatory response was a confined method. Glucocorticoid, which is regularly used in CPB, can affect SIRS in many methods. This study evaluates the efficiency of preoperative methylprednisolone administration in CPB in limiting the inflammatory response in clinical trial by observing the change of the TNF- α and IL-10. And compare the effect of giving methylprednisolone one hour before an operation to the common practice of adding methylprednisolone to the cardiopulmonary bypass circuit prime.Methods: 30 randomly allocated paediatric patients undergoing open heart operation with cardiopulmonary bypass in cardiac surgery department of the Fourth Hospital of Hebei Medical University. The all patients were devided into 3 groups: Group A (Prime-DXM n=10): received no preoperative medication, but dexamethasone (1mg/kg) was added to the...