Effect Of ABL On Matrix Metalloproteinase-2 And Its Tissue Inhibitor After De-endothelium

Objective: The prevention and treatment of restenosis after percutaneous transluminal coronary angioplasty (PTCA) has become the focus in the field of cardiovascular diseases. Restenosis (RS) is a result of the concomitnat contribution of intimal hyperplasia as well as vascular remodeling, which depends on alteration of proteolytic balance within the arteral wall toward extracellular matrix (ECM) breakdown. Matrix metalloproteinases (MMPs) is one of the important proteinases that can degrade all the protein component of ECM. On the other hand, there is a kind of endogenous tissue inhibitor of metalloproteinases (TIMPs), which can inhibit the activity of MMPs. In the vasculature, MMP-2 and TIMP-2 play an esstensial role in maintaining the ECM stability, l-o-acetylbritannilactone (ABL) is a new active compoud isolated from Inula Britannica-F. Previous studies have suggested that ABL has a potent anti-inflammatory activity. However, effect of ABL on RS is unclear. In the present study, we investigated the expression of MMP-2 and TIMP-2 in vascular wall after balloon injury model and demonstrated the effect of ABL on the neointimal proliferation and the expression of MMP-2 and TIMP-2 after balloon injury.