Protective Effects Of HXTML On Myocardial Ischemic Rats Induced By Isoproterenol And On The Expression Of VEGF And BFGF

Coronary atherosclerotic heart disease (CHD) is one of most common disease threatening human's health and myocardial ischemic is its essential pathology process. HUO XUE TONG MAI LING (HXTML), a kind of traditional Chinese medicine, was established on the traditional medicial theory of Qixue and on many years of clinical experiences. It contains some effective medicinal herbs in preventing and protecting myocardial ischemia. Its better effects on CHD have been proved by a great deal of clinical evidence. The researching measures of serology, radioimmunoassay and immunohistochemistry, etc are to explore its functional mechanism and provided a basis for further utilization.Objective: To study the protective effects and mechanism of HXTMC on myocardial ischemic rats induced by isoproterenol (ISO).Methods: 50 healthy male Wister rats were randomly divided into five groups namely blank control group, model group, Aspirin group, HXTMLmax and HXTMLmin group, 10 rats in each group. Each rat had been recordâ…¡electrocardiographic (ECG) before the experiment. Saline were given to Blank control group and Model group at 10ml/kg...