The Study Of The Relation Of The Level Of Vascular Endothelial Growth Factor And Basic Fibroblast Growth Factor The Efifcacy Of Chemotherapy With ShenYi Camplus Inadvanced NSCLC

Objective:To compare the clinical effects and adverse reactions of NSCLC by the treatmentof ShenYi Capsule plus chemotherapy or chemotherapy alone，and the diversity of thelevel of VEGF and bFGF.Methods:Patients who were enrolled were divided into ShenYi Capsule plus chemotherapygroup and chemotherapy group. chemotherapy include：Gemcitabine1000mg/m2iv-drip d1,8; cisplatin75mg/m2ivdrip divided into3days with a21-day cycle, Docetax-el75mg/m2ivdrip d1; cisplatin75mg/m2ivdrip divided into3days with a21-daycycle; Pemetrexed500mg/m2ivdrip d1; cisplatin75mg/m2ivdrip divided into3dayswith a21-day cycle; patients in experimental group were accepted chemotherapy plusShenyi Capsule20mg bid po,at least6weeks. Patients in control group only acceptedchemotherapy.Then the blood was drew before the treatment and after the1st and2edcyle，to detect VEGF and bFGF by Elisa. observed adverse reac-tions in the two grou-ps after chemotherapy.Results:1.22persons were enrolled in the Shenyi Capsule group,21were enrolled in thechemotherapy group. There were no CR patients in both groups, in Shenyi Capsule pl-us chemotherapy group, PR8(36.3%), SD10(45.5%), PD4(18.2%) with RR8(36.3%) and clinical benefit81.8%,，in chemotherapy group, PR7(33.3%), SD9(42.6%), PD5(23.8%) with RR7(33.3%) and clinical benefit76.2%,the different inthe clinical benefit between Shenyi Capsule plus chemotherapy group and chemothera-py group has no statistically significance（p＞0.05）.2.The difference in VEGF and bFGF in Shenyi Capsule plus chemotherapy grou-p and chemotherapy group has no statistically significance（p＞0.05）. 3. The influence of clinical factors to VEGF and bFGF level: we analyzed clinic-al factors including sex, age, ECOG, histology, clinical stage. Among them, only theinfluence of clinical stage had statistical significance (p＜0.05)..4. Adverse reactions and QOL improvement:compared with chemotherapy gro-up, Shenyi Capsule plus chemotherapy group can reduced the gastrointestinal reacti-ons and myelo-suppression and improved QOL.And have satisticacl significance (p＜0.05).Conclusion:1. Observation group and control group before and after chemotherapy serumVEGF and bFGF levels were not affected.2.Sex, Age, ECOG, Histology, do not affect the levels of VEGF and bFGF in obs-ervation group and control group before chemotherapy after one cycle and2cyclesof serum VEGF and bFGF level changes had no effect.3.Clinical stage affect the staging of NSCLC patients, serum VEGF and bFGFlevels in the higher its peripheral serum levels of VEGF, bFGF, the higher of clinicalstage; serum VEGF, bFGF levels were not affected after one cycles/2cycle of chemo-therapy.4. There is positive correlation between VEGF level and bFGF level.5. Compared with chemotherapy group, Shenyi Capsule plus chemotherapy gro-up can reduced the gastrointestinal reactions and myelo-suppression and improvedQOL.