Effects Of Spironolactone And Losartan Therapy On Hemodynamic Parameters And Cardiac Collagen Proliferation After Myocardial Infraction In Rats

Studies have demonstrated that left ventricular remodeling in post-infarction is a very important affective factor in heart failure, even cardiac sudden death. RAAs play an important role in LV remodeling after AMI. Preventing and improving LV remodeling after AMI has become a focus in research areas of cardial vascular disease. Clinical trials and animal experiments suggested that ACEI reduced the post-MI cardiac remodeling, but the phenomenon of "Aldosterone escape" caused by ACEI during the treatment of heart failure have showed the limited effect of ACEI.Aldosterone has physiological effect on heart, independent on angiotensin completely. Aldosterone promotes cardiac fibroblasts to produce collagen. In hypertensive rats with aldosteronism, the synthesis of cardiac collagen increases, and so aldosterone plays an important role in the information and development of cardiac fibrosis. More recently,investigation suggested that aldosterone might be synthesized in myocardium tissue, cardiac Aid level significantly raised in the non-infracted areas of left ventricle after infarction, and accompanied with collagen proliferation. In 1999,RALES proved that antagonism...