Research Of New Traditional Chinese Medicine Kangxintongmai Capsule

"Kangxintongmai" is a scientific-researching recipe with thepurpose of activating the blood circulation, digesting the extravasatedblood,dredging the the blood vessel and relieving the pain. It iscomposed by total glucosides of red paeony root(TGRP) and totalflavone of Pagodatree Flower Bud(TPPB). The former is primarymedicine with the function of clearing the foul blood and relieving thepain,the latter is subsidiary medicine with the function of cooling theblood.Suitable usage of the tow can cool the blood and drege thevessel,then the pain of heart will relieve.The pharmic affection of the formular shows that "Kangxintong-mai" can expand coronary artery,resist the coronary atherosclerotic,relieve the pain and lower the oxygen-consumption of cardiac muscle.Traditional medicine dosage forms are mainly soup, pill, powder,ointment and small pill. inpress people its coarseness, bigness,blackness. on the contrary to western medicine, its bulk is bigger,coller is worse, smell is not better, and it is difficult to carry, to takeand it is slow to be absorbed. In order to overcome this disadvantage,lots of experts in pharmacy alternate the traditional medicine dosageforms with introducing many dosahge forms of western medicine. Inthis paper, kangxintongmai capsule---the new dosage of traditionalmedicine was developed with active parts of chishao(Red PaeonyRoot)and huaimi (Pagodatree Flower Bud)) as raw medicinal materials.Herein, patent for kangxintongmai capsule was applied for.According to the optimal results of orthogonal design experimenton extract process of chishao, extract powder was obtained by treatingwater-boiled liquid through macroporous resin with 20% alcohol aseluent and then evaporating the extract with vacuum. Herein, an activeconstituent liquiritin was isolated from extract powder by columnchromatography method. Then, According to the optimal results oforthogonal design experiment on extract process of huaimi, extractpowder was obtained by dissolve with alkaline water and thenprecipitated with acid water and then evaporating the extract withvacuum after the herb was boiled with 80% alcohol.The reasonableness and stability of the pharmaceutical technologyare proved by the research of pharmacodynamics contrast experimentand the middle scale production on the basis, using advanced analyticaltechnique the quality standard of the medicineis studied and thequality-controlling program is laid down. Through those above-mentioned rese-arches, the total pharmaceutical work before clinic research fixed thesecond class new traditional Chinese medicine stipulate in "The Methodsof Examining and Approving NewMedicine"...