The Effect Of Danggui Shaoyao San And Tiao Xin Fang On Differentially Expressed Genes In Hippocampus And Cortex Of SAMP8

Alzheimer's disease (AD) is one of the most prevalent progressive, neurodegenerative diseases, which primarily affects the elderly population.This paper found many differential expression genes in the hippocampus and cortex of SAMP8 after administrated with DSS and TXF, These genes include: mitochondrial gene, S21 Rn18s and 18S; ribosome gene MT0C1, UQCRFS1 and mitochondrial 12S ribosomal RNA; substance metabolism gene STUB1 and UBE2D2; material transduction gene BNPI, AMF-R and Trim3; and signal transduction gene Rps6kal, Tend, DUSP12, Rab26 and Map4k6-pending; DNA replication gene Fhit and GANP; substance metabolism gene STUB1, UBE2D2; DNA repair gene ERCC5; transcription gene Ssu72; cystoskeleton gene Dynclh1; immune gene Mink; membrane protein gene Itm2c; neuron differentiation gene Mib and lots of function unknown genes and un-sequenced clones. Then, 4 of these genes were identified by QRT-PCR. These genes are closely related with some functions of hippocampus and cortex. It suggests those genes are related with the learning and memory deficient or pathology change in brain of SAMP8. They are potential gene targets of drugs to therapy AD.