Protection Effect Of Phosphatidylcholine Extracted From Livers On CCl4 Damaged Hepatoytes

Phosphatidylcholine, also called Lecithin, is an important constitution of cell membrane, and functions as a protection layer. It can restore cell membrane damaged by free radical. Phosphatidylcholine contains choline, which has affinities to fat. So it can transport fat out of liver by blood in phospholipids, to prevent the formation of fatty liver. Phosphatidylcholine has sanitarian effects on mind, for it provides substances that can form acetylcholine, which is a nerve product. It also be used as liposome and anti-cancer drugs. Furthermore, it has broad application prospects in food, medicine, toiletry and so forth.Liver is the center of metabolism and extremely rich in PC. Except for the CDP-Choline pathway, it also has a special PC synthesis pathway in mammals, in which phosphatidylethanolamine N-methyltransferase catalyzes phosphatidylethanolamine to form PC. It has been reported that the activity of PEMT decreases when pathological changes occur in livers. Our lab transfected hepatoma with PEMT2 overexpression gene, and found that the growth of the cell is remarkably inhibited. Moreover, PEMT2 overexpression could induce apoptosis. It suggests that PC in livers may have unique functions.CC14 is commonly used to study hepatotoxicity, for it can copy liver damage perfectly. In this well-characterized model of free...