Effect Of Dipeptidyl Peptidase IV(CD26/DPPIV) And Inhibitors In The Mobilization And Homing Of Haematopoietic Stem Cells

Background:It is a system engineering that the haematopoietic stem cells transplantation ( HSCT), involving many courses,such as stem cell biology, transplantation immunology,hematology and radiation medicine.According to the source of haematopoietic stem cell(HSC), its can be divided into the Bone Marrow transplantation( BMT), Peripheral blood stem cell to transplantation( PBSCT), Cord-blood haematopoietic stem cell transplantation (CBT). Seening the history's Development of the HSCT experience :The earlier explore of BMT, HLA detection, the CD34+ stem cells transplantation,the fetal liver transplantation , Cord-blood stem cell transplantation and pure CD34+ cells transplantation,Nonablative stme cell transplantation . It was total provided 2,0376 times for patients to Allogeneic hamatopoietic stem cell transplantation (allo-HSCT)in the National Marrow Donor Program(NMDP)by the end of 2004, And 89.1% are used for the malignant tumor treatment. According the international Bone Marrow Transplant Registry, no genealogical allo-HSCT had carried out with 5307 case of Acute Myelogenous Leukemia (AML),the survival rate of 3 years is 41%.Domestic bone marrow database has also been founded Recently. Everywhere in whole country has set up public cord blood stem cell bank one after another.lots of hospitals or centers had been processed this kind of technique ,and the case has been developed a lot.It is thought that HSCT with a kind of clinical important treatment means, just develop rapidly in the scope of the world, and make many disease that couldn't cure enough in the past got a valid treatment. Although it has got important...