The Study Of Adiponectin And TNF-α In The Etiopathogenisis Of Gestational Diabetes Mellitus

Background: As a special type of diabetes mellitus,gestational diabetes mellitus(GDM) happens in the intermediate and advanced stage of gestation. GDM makes the mortality and morbidity of fetus and pregnant women increase,so it is given importance in the perinatal field .Though the etiopathogenisis is still unknown ,most of the scholars think that the reduction of the insulin sensitizing agent and the defect of the insulin secretion and the increasing of some anti-insulin substance make joint action in the etiopathogenisis of GDM in the advanced stage of gestation . The studing and researching show that Adiponectin and TNF-αplay a part in the etiopathogenisis of T2DM,and GDM is prophase stage ahead of the T2DM.Wether Adiponectin and TNF-αplay action in GDM are rarely reported.Objective:To investigate the effect of Adiponectin and TNF-αon the etiopathogenisis of GDM and the relationship between Adiponectin and TNF-α.Methods:The blood samples were collected from 29 gestational diabetes mellitus groups,25 impaired glucose tolerance(IGT) gestational groups and 26 normal glucose tolerance (NGT) gestational groups.Fasting serum Adiponectin,TNF-αand glucose,insulin during 75g oral glucose tolerance test(OGTT) at 0,1,2,3h were measured by radioimmunoassay and ELISA.Insulin secretion was assessed by the homeostasisβ-cell function index(HOMA-HBCI),Insulin resistance by the homeostasis model insulin resistance index (HOMA-IR).The differences in HOMA-IR,HOMA-HBCI,Adiponectin and TNF-αbetween three groups were compared and the relationship between fasting Adiponectin,TNF-αand...