Guinea Pig Model Of Ischemia/repererfusion Induced By Thrombus/thrombolysis Method And The Effects Of Atrial Natriuretic Peptide(ANP) On Ischemia/repererfusion Cochlea In Guinea Pigs

1. AimTo ascertain a new method for establishing an animal model of cochlear ischemia/reperfusion. To find out the cochlear effect of ischemia/ repererfusion model induced by thrombus/thrombolysis method. And to investigate the effects of atrial natriuretic peptide (ANP) on ischemia/ reperfusion cochlea in Guinea pigs.2.Method2.1 The guinea pigs were randomly allocated into five groups: normal group, sham operation group, ischemia group, reperfusion group and saline group. Anterior inferior cerebellar artery (AICA) was exposed by operation via the base of skull. In ischemia group, FeCl₃ solution was used to induce the formation of thrombus in AICA. In reperfusion group, animals were injected urokinase (UK) through left external jugular vein after the formation of...