The Experimental And Clinical Studies On Central Retinal Vein Occlusion Treated By Two-step Laser-induced Chorioretinal Venous Anastomosis

[Purpose] To evaluate the validity and security of two-step laser-induced chorioretinal venous anastomosis (LCRVA) for treatment of central retinal vein occlusion (CRVO)[Methods] Two sections, experimental part and clinical part, were included in our study. Part I : CRVO models were established in 22 (44 eyes) of 30 rabbits by photodynamic method. In 15 rabbits with bilateral CRVO, one eye of each animal was randomly treated to rupture the Burch's membrane and the adjacent venous wall by using multiple-frequency Nd:YAG and Nd:YAG laser devices respectively. Another eye was assigned as CRVO control group. Of 4 rabbits with unilateral CRVO, two underwent LCRVA, and others were as CRVO control group. Fundus fluorescein angiography (FFA) and Electroretinography (ERG) was taken before treatment, as well as 4h, 1d, 3d, 1week, 2weeks, 3 weeks, 4 weeks, 8 weeks, 12 weeks and 16 weeks after treatment. Histopathologic examination was taken at the 16th week. Therapeutic effect was determined by the results of ERG, FFA and histopathologic examination. Part II: Eighteen consecutive patients (18 eyes) with non-ischemic CRVO were recruited. The first 13 patients underwent...