Effect Of Nimodipine On Blood-labyrinth Barrier Permeability Following Cochlear Ischemia/reperfusion Injury In Guinea Pigs And The Protecting Function Of Dexamethasone

ObjectiveTo investigate the effects of intravenous application of nimodipine on blood-labyrinth barrier permeability following cochlear ischemia/reperfusion injury in guinea pigs and the protecting function of dexamethasone.MethodsThe guinea pigs were randomized into six groups: nimodipine injection ischemia group (group A), nimodipine injection reperfusion group (group B), dexamethasone injection ischemia and nimodipine injection reperfusion group (group C), nimodipine and Dexamethasone injection reperfusion (group D) saline injection ischemia group (group E), and saline injection reperfusion group (group F). Thrombus formation upon the anterior inferior cerebral artery (AICA) induced by Fecl₃ was used to develop the cochlear...