The Relationship Between The Expression Of The Chimera And The Effects On The Rats After Small Intestine Transplantation By Injecting Allogenic Bone Marrow Into Thymus

Organ transplantation,one of hot medical fields has gained great achievement as an alternative for the treatment of some diseases of terminal stage, but rejection following organ transplantation have still been puzzling tough problems. Immunodepressant plays a pivotal role in preventing and curing graft rejection in both research and clinical practice, but it can cause side effects such as hypertension, hepar and renal toxicity, severe opportunistic infection, malignant tumor and even malfunction of grafts, etc. Nowdays, hot and tough problems in organ transplantation field are how to induce immune tolerance of graft. Objectives1. To establish the models of acute rejection on the rats after small intestine transplantation by injecting allogenic bone marrow into thymus.2. To study the level of the sIL-2R and TNF-a in blood serum in different periods of small bowel transplantation by injecting allogenic bone marrow into thymus, and the relationship between the sIL-2R and TNF-a and acute rejection.3. To analyze the changes of the chimera expression in serum during small...