EEG, Spacial Learning And Memory, And Hippocampal Ultrastructure In Heat-stressed Mouse

As the global temperatures continue to warm, in recent years heat waves during summer months have struck many areas. The number and intensity of extreme weather events, such as heat injury and heat stroke, might increase. It is widely recognized that high temperature conditions may constitute a major public health threat. The soldiers working in new conditions are at a particularly increased risk of mortality from ambient heat exposure. Excessive heat can lead to a life-threating illness characterized by an elevated core body temperature and central nervous system dysfunction that results in coma, convulsions, or cognition decreased. So it is important to investigate the results of heat stress on central nervous system in animal models.The role of brain in high temperature conditions is not clear. We expect to gain some information from heat-stressed animal models. In the experiment, we established acute heat-stressed mice models. Different aspects were showed in my study, such as behavior, EEG, spacial learning and memory. Nearly all cells respond to sudden heating by producing heat-shock protein or stress proteins. Increased levels of heat-shock proteins in a cell induce a tolerance to heat stress, allowing the cell to survive. The mechanism by which heat-shock proteins protect cells may relate...