The Correlations Between Levels Of Homocysteine And Fibrinolytic System, Severity Of Coronary Stenosis In Patients With Coronary Heart Disease

In many countries, especially in the developed countries like America and some west European countries, atherosclerosis(AS) is one threatening disease to human health. During the past years, an obvious ascending trend has also been taking on morbidity and mortality of coronary heart disease (CHD) which links to multi-liability factors in our country. There are quite a number of persons with CHD, who are with low scores of conventional risk factors such as: age, sex, smoking, hypertension, hyperlipemia, diabetes mellitus, family history of CHD. Besides, there are still many difficulties in correcting or killing these risk factors. For this reason, it is a very important subject for medical science to discover its other risk factors and investigate pathogenesis and its prevention. There has been a wealth of epidemiological evidence that homocysteine (Hcy) is a new independent risk factor of CHD. The possible mechanism of Hcy in CHD has relation to induce vascular endothelial cell injury, promote vascular smooth muscle proliferation, and destroy the balance of fibrinolytic system. The effects of Hcy and fibrinolytic systemic disorder on atherosclerosis have caused much attention in the past years. HHcy may reduce the activity of fibrinolysis function by increasing the levels of antigen of PAI-1, decrease of activity of fibrinolysis function, and cause the clearance of fibrin to reduce ,...