The Efficacy Of Autologous Bone Marrow Mononuclear Cells Transplantation In Patients With Myocardial Infarction And Dynamic Changes Of Basic Fibroblast Growth Factor After Transplantation.

Background: Coronary heart disease is a chief offender to the human being health.Recently the mortality rate of acute myocardial infarction(AMI) have been drawdown significantly because of cardiovascular drugs therapy and percutaneous coronary interventional therapy, but the morbility rate and annual mortality of chronic heart failure(CHF) after AMI is very higher until today .The annual mortality of CHF is about 20-40% according to multi-clinical studies. Professor.Braunwald E predicted that CHF is going to be the most severe epidemic disease in 21century. Heart transplant is considered as the gold standard to treat the patients who remain refractory to maximum medical therapy at present. However, this approach is limited by problems such as donor organ rejection, untoward effects of immunosuppression, disparity between the number of the donors and recipients and so on. Althought risk factor controal, pharmacological treatment using β-blockers and angiotensin converting enzyme inhibitors, percutaneous coronary intervention, cardiac resynchronization therapy, coronary artery bypass graft and implantation of left ventricular assist devices have improved the quality of life for heart failure patients,most of these therapeutic options fail to address the root cause of the problem characterized by the inadequate intrinsic repair mechanism of the heart, which make the heart entering into compensatory vicious cycle of left ventricular remodeling. The existence of resident cardiac muscle stem cells is a good omen but their number is too...