Expression Of MAPK In Human Esophageal Squamous Cell Carcinoma

Background and Purposes: Esophageal carcinoma is one of the most common fatal cancers of the world, especially in China. In our country, the incidence of esophageal carcinoma is only less than lung cancer, gastric cancer and liver cancer, and most of them are esophageal squamous cell carcinoma(ESCC), although esophageal adenocarcinoma is more than ESCC in many developed countries. Like other kinds of carcinoma, the genesis and development of esophageal cancer relat to cell signaling pathway. Mitogen activated protein kinases (MAPKs) are the important members of MAPK signaling pathway which include: Extracellular signal-regulated protein kinase(ERK), C-Jun N-terminal kinase (JNK) and p38. They can transduce extracellular signals to cellular response and play an important role in complex cellular programs like proliferation, differentiation, development, transformation and apoptosis. This study was designed to investigate the expressions of three primary members of MAPKs: ERK1, p38 and JNK2 in ESCC , in order to explore the role of MAPK in genesis and development of ESCC and their association with clinical pathlogical factors.Material and Methods: (1)35 surgery samples were obtained from AnYang Tumor Hospital. Every sample conteins advanced stage ESCC and nomal esophageal mucosa. And 15 of the 35 samples were found to have early carcinoma in their perineoplastic tissue. (2) The expressions of MAPK family members: ERK1, P38 and...