The Expression Of TfR1mRNA, Fn MRNA And IRP1mRNA In The Placenta With Different Maternal Iron Status

Iron is an essential nutrient and vital for many important cellular processes .Iron deficiency (ID)has been a global problem ,severe iron deficiency may lead to iron deficiency anemia(IDA), and IDA is the most common nutritional deficient disease in the world .Because of the severely increased iron requirements of expansion of maternal erythrocyte mass and the rapid growth and development ,pregnant women and infants are recognized as the groups who are most vulnerable to ID or IDA.39% of schoolchildren and 52 % of pregnant women are ID .Maternal ID or IDA during pregnancy can result in serous problems both for the mother and for the developing fetus.There are several regulatory mechanisms in different levels to apply enough iron for fetus to keep the fetal invariable iron supply when maternal ID or the fetus with increased iron needs occurs .The process is :when ID occurs ,the mother's body can mobilize maternal iron stores ,most of which come from the hepatic iron stores ,and there are a series of changes for hepatic level of iron mechanism ,in the same time ,there are corresponding changes of maternal duodenal molecules involved in duodenal iron absorption and transport to increase the maternal duodenal iron absorption and transport and cater for the iron requirements of the growing fetus .The placenta is the only interaction between mother and fetus ,so there must be some changes for the placental iron transport and regulation on the placental level.