Control Study Among MRI Features, Pathology, Molecular Biology Of Meningioma

Background and purpose: Meningiomas is one of the most common benign tumors of central nervous system. It accounts for 15%~20% of the intracranial tumors. Meningiomas have a predilection to happen in 40-60 years of age. Disease incidence of woman is twice than that of men. Although most of the meningiomas are benign tumors, there are about 2%~10% of them which have malignant growth behavior and prone to recurrence and extracranial metastasis. It's very important for surgical operation to get the correct information of meningiomas about location, nature, blood supply , peritumoral brain edema (PTBE) and invasion. Imageology diagnoses of meningiomas mainly include plain skull X-ray, angiography CT and MRI. Because of the high resolution of soft tissue and multi-axial imaging, it is of great value in presenting the location and qualitation of meningiomas with MRI. With the progress of oncomolecularbiology, forming mechanisms of tumor vessel is illuminating gradually, and the investigation of the relationship between meningiomas' biological behavior and neovascularization is also getting deep. Research of meningiomas' therapy with antivasiformation is impressing more and more. Meningiomas' micro vessel density (MVD) can be evaluated by counting the marked vessels which were stained by endothelial cell marker—CD34. MVD will help to reflect vesiformating...