The Experimental Research Of Zhejiang Xinnaokang Soft Capsule

Objective: Carry on a research to the Zhejiang volatile oil, refine its major constituent citral, the obviation carcinogen safrole, then prepare soft capsule ,and enhance Miao medicine Zhejiang value in use.Method: Adopt orthogonal experimental design to optimize chemical technology of detaching safrole and refining citral from Zhejiang volatile oil;use compacting method to prepare soft capsule and research making craft condition;use gas chromatography to Zhejiang volatile oil, take off poisonous oil and the Zhejiang xinnaokang soft capsule carry on a quality control, building up quality standard.Result: The best craft of using a chemistry method to remove safrole and refine citral from the Zhejiang volatile oil in order to respond temperature 5℃, time 7 hours and the mol ratio of sodium sulfite and citral is 2.1: l;The adoption more mature craft makes a soft capsule;The valid composition citral which uses gas chromatography and thin layer chromatography method to soft capsule carries on settle sex fixed amount control, and draw up soft standard drafted plan of quality of the Zhejiang xinnaokang soft capsule.Conclusion:The craft which uses a chemistry method to remove safrole and refine citral from the Zhejiang volatile oil is stability and feasible, through the examination, the safrole removes more completely, the pure degree of the citral is higher;use gas chromatography method to the Zhejiang volatile oil and soft capsule carry on the stability credibility of the quality control;Make the craft of soft capsule according to the result elucidation of the quality examination is feasible.