| Objective: To evaluate multi-voxel proton magnetic resonance spectroscopy (1HMRS) and apparent diffusion coefficient (ADC) in cerebral astrocytomas grading and differentiation.Material and Methods: Nineteen healthy volunteers were evaluated as a control group that underwent conventional MR imaging, multi-voxel 1HMRS, and diffusion-weighted imaging (DWI). Forty-seven patients with histologically or clinically proved brain diseases (twelve high- and ten low-grade astrocytomas, ten metastases, nine meningiomas, three malignant lymphomas, and three brain abscesses) were prospectively evaluated with contrast material-enhanced MR imaging, multi-voxel 1HMRS (PRESS, TR/TE=1500/135ms), and DWI (b=0 and 1000s/mm2) before surgery. In the control group, the metabolite peak area of N-acetylaspartale (NAA), choline compounds (Cho), and creatine compounds (Cr) were measured in the bilateral frontal lobe, occipital lobe, temporal lobe and parietal lobe, and bilateral gray matter and white matter of parietal lobe. In the patient group, the metabolite peak area of NAA, Cho and Cr were measured in the solid component, peritumoral region and cystic region of tumors. And the ratios of NAA/Cr, Cho/Cr, NAA/nCr, Cho/nCr, Cr/nCr, Cho/nCho and Cho/NAA were calculated. Lipid (Lip) and lactate (Lac) were observed to appear or not. ADC maps were calculated and regions of interest (ROI) were manually placed over areas of solid component, peritumoral region and cystic region of tumors, and various areas of the control group.Results: The metabolite peak area of various parts of normal brain parenchyma was different, but there was no significant difference between left and right of the same part (P>0.00179, corrected P value). NAA/Cr and Cho/Cr ratios of white matter were higher than that of gray matter in parietal lobe (P<0.05). There was significant difference between...
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