A Molecular Epidemiological Study On The Relationship Between The Genetic Polymorphisms Of Interleukin Gene And Susceptibility To Breast Cancer

The incidence of breast cancer has been increasing significantly in the last two decades in China, and breast cancer is the leading cause of cancer-related deaths for women in most developed countries. A wide diversity of genetic damage induced by endogenous metabolites and exogenous hazards, such as exposure to ultraviolet, ionizing radiation, and chemical carcinogens, may contribute to the etiology of breast cancer. Inflammation, chronic inflammation in particular, may be one of the important host responses that result in oxidative stress and therefore may contribute to tumor promotion and progression. Many studies have suggested that environmental and genetic factors may play important roles. So, it is urgent to find out BC etiology and take effective prevention measures. To reach this target, a hospital-based molecular epidemiological study on BC was conducted in Jiangsu Province.