Susceptibility To Impulse Noise Trauma In The CBA And The C57B/6bkl Mouse

Objective to study the sensitivity to impulse noise in CBA and C57B/6bkl mouse. Methods eight groups were divided. Group 1 CBA mice (n=9) were exposed to 50 impulses of 160dB SPL noise. Group2 CAB mice (n-10) were exposed to 100 impulses of 160dB SPL noise. Group3 CBA mice (n=10) were exposed to 150 impulses of 160dB SPL noise. Group4, 5 and 6 C57B/6bkl mice (n=10) were exposed to 50,100,150 impulses of 160dB SPL noise. Group7 and Group8 CBA (n=10) mice and C57B/6bkl mice (n=10) were control groups. They were not exposed noise. ABR thresholds were determined prior to, 24 hours and 28 days after impulse noise exposure. Results The CBA mice were only shown temporary Threshold shifts after 50 times impulse noise. The C57B/6bkl mice were shown temporary Threshold shift (TTS) and permanent threshold shifts (PTS) after 50 times impulse noise. Both the CBA mice and C57B/6bklmice were shown temporary and permanent threshold shifts after 100 and 150 times impulse noise, while no TTS and PTS in control groups. Conclusion The C57B/6bkl mice were more sensitivity than the CBA mouse to impulse noise. Cochlear morphological results further showed that the C57B/6bkl mice have higher sensitivity to impulse noise trauma than the CBA mice.