Chang Of Plasma AVP Level In Patiens With Obstructive Sleep Apnea Syndrome And The Clinical Application Of Actigraphy

Background:In obstructive sleep apnea syndrome (OSAS) the repeated and intercurrent apnea-hypopnea occured during sleep.Consequently, cyclical alterations of arterial oxygen saturation were observed, with intermittent oxygen desaturation developing in response to apneas followed by resumption of oxygen saturation during hyperventilation.In addition arousals and microarousals followed by apnea-hypopnea during sleep, which caused sleep fragmentation.In OSAS the stability of the internal environment was disturded because of repeated apnea/hypopnea,oxidative stress and sleep fragmentation.In addition the sleep architecture was damaged,for instrance the deeper sleep and the rapid eye movement sleep was decreased.Above all influenced the activity of the stress system. It was reported that the effect agents of the stress system eg. corticotropin releasing hormone and cortisol in circulation increased.Arginine vasopressin(AVP) which was a kind of neuropeptide increased in stress.At present the literature varied regarding the effects of the OSAS on the hypothalamic-pituitary-adrenal system(HPA),itself.These studies had primarily focused on the effects of continuous positive airway pressure(CPAP) and not been claritied.Auto-continuous positive airway pressure (auto-CPAP) automatically adjusted the level of mask pressure to the patient's sleep behavior,thus improved the sleep quality.The plentyful iatric resource would be used if patients in OSAS who were long-term treated by auto-CPAP at home and need the regular evaluation of therapeutic efficacy were assessed by traditional polysomnography.Another in the process of polysomnography some cases complained the examination influenced the sleep quality.