Hepatoprotective Effect Of Acanthoic Acid On Fulminant Hepatic Failure Induced By D-galactosamine And Lipopolysaccharide In Mice

OBJECTIVE: To study the protective effect of Acanthoic acid on fulminant hepatic failure in mice.METHODS: fulminant hepatic failure injury models induced by D-galactosamine(D-GalN) / Lipopolysaccharide(LPS) in mice, and the levels of serum enzyme ALT AST and TNF-a ; the DNA damage in liver; the effects of survival on acute liver injury with pretreatment Acanthoic acid were observed. RESULTS: The oral administration of the water extract and the ethanol-insoluble part of the water extract significantly reduced the levels of serum enzyme ALT AST and TNF-α Activities, and significantly suppressed DNA damage on mice liver.CONCLUSION: From the results of the present study, we revealed for the first time that the Acanthoic acid had an in vivo effect on both apoptosis and necrosis of hepatocytes in fulminant hepatic failure induced by GalN/LPS.