The Expression And Clinical Signifance Of Colony Stimulating Factor Receptors And Drug Resistance Protein In Acute Leukemia

Background and objective of investigation:1. Background:Nowadays, the regulation of cytokines to hematopoiesis is an issue in the world. Both granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) can regulate proliferation, differentiation and maturation of hemapoietic stem cells and progenitors. And they also play an important role in the regulation of hematopoiesis and the process of many malignant diseases of hematology, for example, acute leukemia (AL). But the mechanism involved is uncertain at present. It was demonstrated that the biological function of G-CSF and GM-CSF were produced through binding to the membrane surface receptors (G-CSFR,GM-CSFR) of effector cells. So elucidating the expression rules of G-CSFR and GM-CSFR and analyzing the relationship between them in patients with acute myelocytic leukemia (AML) and acute lymphoblastic leukemia (ALL) would supply important theoretical basis to clinical application of colony-stimulating factors appropriately and supply new therapeutic strategies for the treatment of AL.At present, recombinated human G-CSF and GM-CSF (rhG-CSF, rhGM-CSF) which can short the granulocytopenic period and febrile days have been generally applied in many hematologic diseases, tumor chemotherapy and bone marrow transplantation, and gained distinguished therapeutic effect. The leukemic cells in the...