The Role Of Folic Acid On AGEs-RAGE And VCAM-1 In Myocardium And Artery Tissue Of Diabetic Rat

Objective:Diabetes mellitus is a clinic syndrome which is related to the interaction of heredity and environment factors. The pathogenesy of diabetes mellitus' various kinds chronicity complications are very complicated, which are result from multitude factors interact. With the increasing incidence and developing course of the disease the inception rate of diabetic cardiovascular disease, it is one of diabetic complications and becomes one of the major dead factors in diabetic patients, is more and more. Diabetic cardiomyopathy is an independent diabetic complication which is a specific cardiac disease of diabetes mellitus. The effects of advanced glycation end products (AGEs) and its receptors (RAGE) produced within the environment of hyperglycemia by diabetes mellitus have been attracted more and more attentions. The interaction of AGEs and RAGE can activat a certain key aignal transduction pathways, which evoke a series of pathological changes in the system of diabetic cardiovascular disease by inducing many oxygen free radicals and cytokines, such as blood vessel' damage, hemodynamics and hemorrheology endothelium abnormality, cell matrix paraplasm and neovascularization. In recent years researches have found that atherosclerosis (AS) is the most common change in diabetic macroangiopathy which is regarded as a disease caused by multiple factors especially chronic inflammation included. The molecular basis of AS is the interaction between leucocyte and vascular cell adhesion molecules (VCAM), VCAM-1 plays an important role during the course of occurrence and development of AS. As one of the important risk factors in diabetic patients, hyperhomocysteinemia (HHcy), which can make effects by multiple mechanisms. Many studies proved that HHcy commonly accompanying with diminution of the serum folic acid, vitamin B12, could be reduced by oral folacin supplementation. At present there are studies about utilizing homomethionin which can reduce the model of hyperhomocysteinemia in rats, then supplement thses rats with folic acid and/or vatamin B₁₂ to observe the changes. But there isn't yet reports about folic acid could impact on AGEs and its receptors and VCAM-1, that stands for inflammatory infiltration, by reducing...