The Study Of Fasting Serum Ghrelin And Visfatin Levels And Their Correlations To Insulin Sensitivity In Patients With Type 2 Diabetes Mellitus

Objective: To measure levels of serum ghrelin and visfatin in obese patients with type 2 diabetes mellitus (T2DM) and non-obese patients with T2DM, and to study their correlations to insulin sensitivity.Methods: Use radioimmunoassay (RIA) to measure fasting serum ghrelin and use enzyme-linked immunoassay (EIA) to measure fasting serum visfatin in 60 type 2 diabetes patients, which were divided into obese diabetic group and non-obese diabetic group due to BMI, and 30 normal controls. The sex, age, height, body mass, waist and hip of all subjects were recorded. Fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), fasting serum insulin (FINS) were measured in all of the subjects. Use Bennett Index to estimate insulin sensitivity.Results: (1) In the obese diabetes, the fasting serum ghrelin was significantly lower than that of the non-obese diabetes (p<0.001) and that of the control (p<0.001). In the non-obese diabetes, the fasting serum ghrelin was significantly lower than that of the control (p=0.005).(2) In the obese diabetes, the fasting serum visfatin was significantly higher than that of the non-obese diabetes (p=0.007) and that of the control (p<0.001). In the non-obese diabetes, the fasting serum visfatin was significantly higher than that of the control (p=0.002).