| Objective : To study the level and change of secreted aspartyl proteinase 2 (SAP2)in serum from rabbits with pulmonary candidiasis albicans . To evaluate the clinical significance in earlier diagnosis of this disease .Methods : Forty male New Zealand White Rabbits, very nearly in weight, wererandomly divided into two unequal groups in quantity, the experimental group 21, the control 19. After being immunocompromised, then experimental rabbits were injected with 0.2ml inoculum containing 1×10~8 blastoconidia through trachea to form the model of pulmonary candidiasis albicans. The control group receive the same volume saline in the same way. Rabbits were respectively killed and dealed on sequence day by day 24 hours later, as the sequence designed beforehand. To observe pathological sections of lung stained with PAS(periodic acid-Schiff) under microscope. To detect the level of SAP2 in serum by ELISA , then compare the level of SAP2 between two groups and analyse the difference depending histopathology change. So that provide an evidence for SAP2 as a good marker to diagnose lung infection of Candida albicans earlier.Result:1, The animal model of Candida albicans infection in lung can be successfully developed by injecting the fungi through the trachea . After the tissue specimens were...
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