Relationship Between Expression Of FAK, PTEN And Tumor Cell Proliferation, Invasion And Metastasis In Breast Carcinoma

Objective:To investigate the expression of FAK (focal adhesion kinase) and PTEN (phosphatase and tensin homology deleted on chromosome ten) in the breast carcinoma tissue, to seek their relationship with tumor cell proliferation, invasion and metastasis, to study the relationship between the cell signaling transduction system mediated by FAK and the carcinognesis, development of breast carcinoma, and to provide the experimental basis of prognosis judgement for breast carcinoma.Methods:Tissues were obtained from 88 patients with breast invasive ductal carcinoma and 25 with breast ductal epithelial benign proliferative disease. The expression of FAK and PTEN were examined by immunohistochemical technique (streptavidin peroxidase conjugate method, SP).Results:(1) The positive incidences of FAK and PTEN expression in 88 cases of breast carcinoma were 68.2%(60/88) and 53.4%(47/88), respectively, which differentiate apparently those of the control group (P<0.01); (2) In breast carcinoma tissues, the expression of FAK was positively related to Ki67 proliferation index, tumor size, axillary lymph node metastasis and clinical stage (P<0.01), the expression of PTEN was negatively related to Ki67 proliferation index, histopathologic grade, axillary lymph node metastasis and clinical stage (P<0.05); (3) In breast carcinoma tissues, the expression of FAK was negatively related to the expression of PTEN (P<0.01); in the breast cacinoma with PTEN postive expression, the Ki67 proliferation index and the emerging rate of axillary lymph node metastasis of the cases with FAK postive expression are apparently higher than those with FAK...