Experimental Studies Of Partial Androgen Deficiency And The Traditional Chinese Medicine Intervention

Background and Aim Associated with advanced age elderly men with low testosterone levels are increasingly diagnosed to have partial androgen deficiency in the aging male (PADAM). Although reports indicate that testosterone supplement therapy (TST) possesses a wide range of beneficial effects for men with PADAM. TST remain controversial and may have adverse effects on the prostate and cardiovascular risk factors. However, Herba epimedii and semen cuscutae are both classical kidney invigorating drug and always apply to menopause. In our experiment, we set up an partial-androgen-deficiency animal model using the reproductive toxicity of cyclophosphamide. Then icariin(ICA) and the substance extracted from the semen cuscutae (SSC) treatment were used to explore the protective effects of ICA and SSC on partial-androgen-deficiency rat.Material and Methods 60 healthy male Sprague-Dawley rats at the age of 15 months, weighed 220-300 g, were divided at random into 5 groups of 12 rats each: the control group (C), the model group (M), the icariin group (ICA), the substance extracted from the semen cuscutae group (SSC)...