Investigation Of ICOS And Transcription Factors Expression On Neonatal CBMC And The Effect Of House Dust Mite On It

BackgroundBronchial asthma is the most common chronic disease of children. The prevalence of asthma has increased steadily in worldwide over the past decades. In China, the prevalence of asthma in children aged 0~14 years increased 1.6-fold from 0.78 % in 1990 to 2.06 % in 2000. All the asthma medicine are used to treat the illness after it occurred, although they reduce asthma symptom, they have no impact on cure of asthma or reduce veduction of asthma prevalence. Moreover it is far from the World Health Organization (WHO) called for the first level prevention of asthma: suppression the sensitivity of the original and / or unusual patterns of airway to prevent asthma from occurring. So far the primary prevention is still in an initial exploratory phase worldwide, it's generally agreed that to step down the prevalence of asthma should begin at birth and neonatal period. Therefore, it's very important to investigate the T cell function of neonate."Hygiene hypothesis"suggests that the improved hygiene in...