A Pilot Study On Percutaneous Perfluorocarbon Emulsion Injection For Improving HIFU Therapy Efficiency

High intensity focused ultrasound (HIFU) is a promising way to treat solid tumors. It developed rapidly in recent decades. HIFU can destroy tumors completely without affecting the tissues on the acoustic pathway and those around the target. The main mechanism of HIFU"kill"tumors includes hyperthermal mechanism, cavitation mechanism and the subsequent mechanisms. The subsequent mechanisms include destroying vessels of tumors, improving the systemic immunology and so on. HIFU has been applied to hepatic carcinoma, kidney carcinoma, breast carcinoma and other solid tumors in multicentres researches at home and abroad. But there are still some problems to be solved. Some researches have showed that remodeling the acoustic environment of tissue (AET) is a promising method to enhance the HIFU therapy efficiency.Dr. Xiao in our institute had made a kind of phase shift perfluorocarbon emulsion (PSPE), it can enhance the efficacy of HIFU therapy, not only for normal tissue, but also for tumors. The mechanism may be PSPE can remodel the acoustic environment, thus more energy deposit in the target. But PSPE is a primary assistor for HIFU therapy, and it is used through vein, so the systemic side-effects of short and long terms must be taken into account. On the other hand, for a new medicine there must be quite a long way to be used in clinic treatment. It is known that for most medicines, there are less systemic side-effects injected locally than which used through vein. On the base of this we prepared a phase shift...