Specific Antitumor Immunity Of Peripheral Blood Cytotoxic T Lymphocytes After High Intensity Focused Ultrasound Ablation For Tumor

OBJECTIVEBased on the previous results, this study was designed to investigate the specific antitumor immunity of peripheral blood cytotoxic T lymphocytes (CTLs) after high intensity focused ultrasound (HIFU) treatment for H₂₂ implanted tumor in mice, and to provide more evidences involved in adoptive immunotherapy with HIFU-activated CTLs for homogeneous tumors.MATERIALS AND METHODS1. Changes in the cellular immune functions of peripheral blood after HIFU treatment for tumor-bearing miceSixty normal C57BL/6J mice were randomly divided into three groups: HIFU group (n =20), sham-HIFU group (n =20), and control group (n=20). The mice in both HIFU group and sham-HIFU group received H₂₂ hepatic carcinoma implantation using the hypodermic injection of H₂₂ cells suspension in the back of each mouse. Seven days after tumor implantation,...