Mechanisms Of Peripheral Blood Cytotoxic T Lymphocytes Activated With High Intensity Focused Ultrasound In The Adoptive Immunotherapy Of Homogeneous Tumor

OBJECTIVEPrevious studies revealed that peripheral blood T lymphocytes had specific anti-tumor immunity in tumor-bearing mice after high intensity focused ultrasound (HIFU) ablation for implanted tumors. This study was designed to investigate the changes in the cellular immune activities of peripheral blood, tumor cell apoptosis and molecular expression of cytotoxic T lymphocyte(CTL)in the implanted tumors after adoptive immunotherapy with HIFU-activated peripheral blood CTLs in tumor- bearing mice, and to provide more evidences of the mechanisms involved in host anti-tumor immune response with CTL adoptive immunotherapy after HIFU treatment.MATERIAL AND METHODS1. Changes in the cellular immune function of tumor-bearing mice...