Experimental Study Of Effects Of Neutrophil Elastase And Its Inhibitor On Focal Cerebral Ischemia-Reperfusion In Rats

Objective:With the changes of natural environment and dietary factors ,the incidence of human cerebrovascular disease is increasing gradually, among which ischemic cerebral vascular disease(ICVD)accounts for 80%.Furthermore middle cerebral artery occlusion(MCAO)accounts for 43% among ischemic cerebrovascular disease ,therefore it is important to sdudy MCAO and to research new drugs.It is reported that activated neutrophils contribute to the secondary damage of cerebral ischemia-reperfusion, which can release multiple proteases, reactive oxygen species , cytokines and so on. Neutropil elastase (NE) is the predominant serine stretch proteolytic enzyme released from neutronphils, which can degrade the basement membrane and other important intercellular matrix.Recent investigations revealed that NE could enhance cytokine production, intercellular adhesion molecule-1 expression, and superoxidase release to cause severe tissue damage in hepatic,...