Prophylaxis Of Transplantation-related Complications After Allogeneic Stem Cell Transplantation In β-thalassemia Major

Allogeneic stem cell transplantation (allo-HSCT) is the only way to cure β -thalassemia major at present. Graft-versus-host disease (GVHD) and hepatic veno-occlusive disease (HVOD) are the main complications of transplantation. Therefore, it's importance how to prevent and treat the complications reasonably and effectively, which was relation with the successful transplantation and overlife quality of patients. This paper will make an evaluation about the hematopoietic re-construction and the incidence of GVHD and HVOD after transplants.A proper number of the cells which are needed in the transplant and suitable protocal for preventing GVHD and HVOD were suggested. Method:52 cases of β -thalassemia major received 58 times of allo-HSCT from June of 1997 to December of 2004. Age of the patients range from 1 to 14(average 6), 34 children were male and 18 children were female. β -thalassemia clinical classification: 36 cases were categorized as class I and class II ,16 cases were categorized as class III. Twenty five patients received allo-HSCT from HLA-matched sibling donors. Twenty seven patients received allo-HSCT from unrelated donor or HLA mis-matched sibling, one of them was two antigents mismatched. Forty three patients underwent bone marrow transplantation, 9 patients under went PBSCT. Three...