| Cilnidipine is a new dihydropyridine (DHP) type of calcium channel antagonist. It is used for treating high blood pressure and angina in the clinical. Doxofylline is commonly medicine for treating acute and chronic obstruction disease. Since calcium channel antagonist can block calcium channel of airway smooth muscle cell and prevent Ca2+ from into cell .Thereby it can inhibit construction and convulsion of airway smooth muscle and dilat bronchus and improve lung function and relief resisting force of pulmonary circulation.Therefore theophylliney species and calcium channel antagonist are usually used together for treating patient who is suffer from asthma with high blood pressure and angina. In order to provid reference about safety and reasonable application of them in the clinical pharmacokinetics of cilnidipine and doxofylline in animal were studied.1.Studies on the intestinal absorption kinetics of cilnidipine and doxofylline in ratsIntestinal absorption kinetics of cilnidipine and doxofylline were studied by situ recirculation in rats.UV and HPLC were used to determine the concentrations of phenol red and cilnidipine. The.results showed that the absorption rate constants (Ka) of cilnidipine at duodenum, jejunum, ileum, and colon were 2.05±0.01,1.95±0.01, 1.96±0.01, 1.82±0.01 (h-1)respectively.Ka from intestine at cilnidipine concentration of 5, 10, 15μg·mL-1were 2.25 ± 0.0069, 2.24 ± 0.0053, 2.24 ± 0.0057(h-1);Ka at pH of 6.4, 7.2, 7.9 were 2.23±0.01, 2.24±0.01, 2.21±0.21 (h-1) .The results showed that the absorption rate constants (Ka) of doxofylline at duodenum, jejunum, ileum , and colon were 0.52±0.01 , 0.72±0.06 , 0.96±0.07 , 1.15±0.08(h-1) respectively.Ka from intestine at doxofylline concentration of 5,10,15μg·mL-1 were 0.53 ± 0.01, 0.51±0.01, 0.51±0.01(h-1);Ka at pH of 6.4,7.2,7.9 were 0.53±0.01, 0.54 ± 0.01,0.54±0.24(h-1). The results showed that the absorption rate constants (Ka) of cilnidipine and doxofylline in rats:cilnidipine was 2.21 ±0.01(h-1); doxofylline was...
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