The Relationship Between HBV Precore Region Mutation And Peripheral T Cell Subsets Status In Chronic HBV Carriers

OBJECTIVE: To explore the relationship between the changes of T cell subsets and HBV precore region 1896 mutation in chronic HBV carriers.METHODS: HBV precore region 1896 mutation and peripheral T-cell subsets were examined in chronic HBV carriers. The results of peripheral T-cell subsets were compared among groups based on HBV precore region 1896 mutation status, HBeAg, age, sex and the quantities of HBV DNA.RESULTS: In comparison with those in health controls, the percentage of CD3~+T lymphocyte cells was no significant difference (t=1.202, P=0.232), the percentage of CD4~+T lymphocyte cells (t=2.725, P=0.007) and CD4~+/CD8~+T cells (t=2.546, P=0.012) were obvious lower, and the percentage of CD8~+T lymphocyte cells was obvious higher ( t=2.606, P=0.010) in chronic HBV carriers. Comparing with HBV precore region mutation negative group, there was no significant difference in the percentage of CD3~+T lymphocyte cells (P=0.789), while the percentage of CD4~+/CD8~+T cell was obvious lower (P=0.033), and there was a trend of decreasing the percentage of CD4~+ T lymphocyte cells and a trend of increasing of the percentage of CD8~+ T lymphocyte cells in HBV precore region mutation positive group. The chronic HBV carriers with HBeAg positive presented the disorder T-cell immune state than HBeAg negative grope: the percentage of CD4~+T lymphocyte cells was lower (P=0.036) and there was a trend of decreasing CD4~+/CD8~+T cells and a trend of increasing of the percentage of CD8~+T lymphocyte cells. The positive rates of...